Pat chicken breasts dry with paper towels. If thicker than ¾-inch, place between plastic wrap and gently pound to even thickness. Season both sides with salt, pepper, garlic powder, and paprika.
Create a three-part dredging station: flour in the first dish, beaten eggs in the second dish, and a mixture of Parmigiano-Reggiano, panko breadcrumbs, Italian seasoning, and onion powder in the third dish.
Dredge each chicken breast in flour (shaking off excess), then dip in egg mixture, and finally press firmly into the parmesan mixture, ensuring even coating on all sides.
Allow the coated chicken to rest uncovered for 5 minutes to help the coating adhere properly during cooking.
Preheat your air fryer to 360°F (182°C) for 3 minutes.
Lightly spray the air fryer basket with olive oil. Spray the top surface of each chicken breast lightly with olive oil as well.
Place chicken breasts in the air fryer basket without overcrowding. Cook for 4 minutes.
Open the air fryer, carefully flip each piece using tongs. Lightly spray the newly exposed top surface. Continue cooking for 3-4 more minutes until golden brown and internal temperature reaches 165°F (74°C).
Remove chicken to a wire rack or plate. Let rest for 3-5 minutes before serving to redistribute juices.